Recent Publications by UAB FacultyMale cancer patient sperm cryopreservation for fertility preservation: 10-year monocentric experience September 16, 2021CONCLUSIONS: The present data confirm the deleterious impact of various cancers on semen quality. Leukaemia was associated with the worst semen quality and the highest number of semen samples that could not be frozen. We suggest that sperm quality may have decreased even before anti-neoplastic treatment and that sperm banking before treatment should be strongly […] Xiao LiuCircular RNAs' cap-independent translation protein and its roles in carcinomas September 16, 2021Circular RNAs a kind of covalently closed RNA and widely expressed in eukaryotes. CircRNAs are involved in a variety of physiological and pathological processes, but their regulatory mechanisms are not fully understood. Given the development of the RNA deep-sequencing technology and the improvement of algorithms, some CircRNAs are discovered to encode proteins through the cap-independent […] Lian HeEfficacy, safety and prognostic factors affecting overall survival among metastatic prostate cancer patients undergoing treatment with (177)Lu-PSMA-617: A single center study September 16, 2021CONCLUSION: PRLT with ^(177)Lu-PSMA is well-tolerated and effective in metastatic prostate cancer patients who have no other treatment options available. The novel prognostic markers found in this study (high platelet count, superscan pattern) were associated with poor overall survival. Soroush Zarehparvar MoghadamScoping the literature on patient travel abroad for cancer screening, diagnosis and treatment September 15, 2021The incidence of cancer is on the rise globally. Under particular circumstances, patients are willing to travel abroad for healthcare treatments. We know relatively little however about patients travelling overseas for cancer-related screening, diagnosis and treatment. Where do patients go, for what treatments, what are their motivations, decision-making processes and treatment experiences? What do we […] Neil LuntDeliberations on Natural Products and Future Directions in the Pharmaceutical Industry September 15, 2021Natural Products (NPs) are molecular' special equipment ' that impart survival benefits on their producers in nature. Due to their evolved functions to modulate biology these privileged metabolites are substantially represented in the drug market and are continuing to contribute to the discovery of innovative medicines such as the recently approved semi-synthetic derivative of the […] Kathrin BuntinDevelopment of a psychosocial oncology core curriculum for multidisciplinary education and training: Initial content validation using the modified Delphi Method September 15, 2021CONCLUSIONS: This proposed core content can enhance and standardize education and training in PSO including APOS' Virtual Psychosocial Oncology Core Curriculum, focused on broadly expanding the PSO workforce, particularly in underserved areas. Next steps include development of core competencies and establishment of online training modules based on this content validation. Sharla Wells-Di GregorioEvaluating Cancer Care Networks; A Case Study of a Lung Cancer Care Network September 15, 2021CONCLUSION: An evaluation tool for (lung) cancer care networks was successfully developed and piloted within a cancer care network. The tool has proven to be a useful method for evaluating collaboration within an oncological network. It helped network partners to understand what they see as important and allowed them to learn about their program's dynamics. […] Anke WindComparing the effect of a consult model versus an integrated palliative care and medical oncology co-rounding model on health care utilization in an acute hospital - an open-label stepped-wedge cluster-randomized trial September 15, 2021CONCLUSIONS: The co-rounding model was associated with a shorter hospital length of stay. Readmissions within 30 days and access to specialist palliative care were similar. Grace M YangInfluence of eye movement on lens dose and optic nerve target coverage during craniospinal irradiation September 15, 2021CONCLUSION: With modern CSI techniques, eye movements result in higher lens doses and a mean detriment for orbital optic nerve dose coverage of Bianca A W HoebenHodgkin lymphoma survivor perspectives on their engagement in treatment decision-making and discussion of late effects September 15, 2021BACKGROUND: Hodgkin lymphoma has a bimodal age distribution with the first peak occurring within young adulthood and the second, among older adults. Although current therapy provides excellent disease control, survivors are at risk of developing treatment-related late effects (LEs). We sought to understand how survivors in active survivorship care perceived their role in treatment decision-making […] Rachel Murphy-BanksThe use of patient-reported outcomes in routine cancer care: preliminary insights from a multinational scoping survey of oncology practitioners September 15, 2021CONCLUSIONS: Only a quarter of the surveyed practitioners reported capturing PROs in routine clinical practice. The implementation barriers to PRO use varied across respondents in different professions and levels of socioeconomic resources. Our findings can be applied to guide planning and implementation of PRO collection in cancer care. Yin Ting CheungInterplay between spirituality and religiosity on the physical and mental well-being of cancer survivors September 15, 2021CONCLUSION: Spirituality is important in the improvement of both pQOL and mQOL of cancer survivors, while religiosity may have some impact on pQOL. Clinicians' incorporation of spirituality into cancer treatment facilitates well-rounded care, which offers measurable improvements for patients with an illness, of which the treatment is often arduous, and uncertain. Anthony J CannonImplementation of a cloud-based electronic patient-reported outcome (ePRO) platform in patients with advanced cancer September 15, 2021CONCLUSIONS: Web-based ePRO tools for patients with advanced cancer are feasible and acceptable without increasing clinical burden. Key lessons include the importance of pilot testing, engagement of stakeholders at all levels, and the need for customization by disease group. Future directions for this work include completion of EHR integration, expansion to other centers, and development […] Olga GeneralovaYoga for chronic chemotherapy-induced peripheral neuropathy pain: a pilot, randomized controlled trial September 15, 2021CONCLUSIONS: Yoga is a feasible non-pharmacological modality for cancer survivors with CIPN, but more information is needed regarding its impact on CIPN and other symptoms. Robert KnoerlRadiation Oncology's Place in Payment Reform: ASTRO Advocates for a Place at the Table September 15, 2021In its current form, the Radiation Oncology Model (RO Model) prioritizes payment cuts over true value-based payment transformation. With significant modifications to the payment methodology, the reporting requirements, and recognition of the unique challenges faced by disadvantaged populations, the RO Model can protect patient access to care, preserve the physician-patient decision-making process, and ensure the […] Anne HubbardRobotic Surgery in Pediatric Oncology: Lessons Learned from the First 100 Tumors-A Nationwide Experience September 15, 2021CONCLUSIONS: Robotic surgery for pediatric tumors is a safe option in highly selected cases. Indications should be discussed by tumor boards to avoid widespread and uncontrolled application. Thomas BlancIntegrating Radiation Oncology Into Undergraduate Medical Education September 15, 2021Cancer is one of the most important public health problems. However, medical education has not advanced at the same rate when it comes to cancer education. Currently, the United States Medical Licensing Examination subject examinations do not cover radiation oncology, prevention, and survivorship planning in its assessment model. Incorporating medical oncology and radiation oncology training […] Mona ArbabA cross-study analysis of drug response prediction in cancer cell lines September 15, 2021To enable personalized cancer treatment, machine learning models have been developed to predict drug response as a function of tumor and drug features. However, most algorithm development efforts have relied on cross-validation within a single study to assess model accuracy. While an essential first step, cross-validation within a biological data set typically provides an overly […] Fangfang XiaTime management: Improving the timing of post-prostatectomy radiotherapy, clinical trials, and knowledge translation September 15, 2021CONCLUSION: Together, this global collaborative review on the postoperative management of prostate cancer suggested a stronger signal for the uptake of early salvage radiation treatment with careful PSA monitoring, more sensitive PSA triggers, and expected access to radiotherapy. Questions still remain on potential exceptions and barriers to use. These require better decision-making tools for all […] Kai Yun OoiRole of poorly differentiated cluster in gastric cancer: is it a new prognosis factor? September 15, 2021CONCLUSION: PDC is a strong prognostic factor in gastric cancer, easily detectable, and feasible. As far as we know, this is the first report in Literature of a strong correlation between PDC and survival in patients with operated gastric cancer. L Sorrentino
